We are a team of bioinformatic researchers at the Sun Yat-sen university Cancer Center, specializing in GI cancer research. Our team is also part of the bioinformatic platform led by Professor REN Jian, which you can learn more about at https://renlab.org/.
Our research focuses on developing new algorithms, applications, and database tools to analyze GI cancer omic data. We also use machine-learning approaches to identify biomarkers for tumor diagnosis and prognosis.
Currently, we are working on several fields, including:
Exploration of Biomarkers for Cancer Immunotherapy
Developing Software and Database related to Cancer genomics
Developing novel targeting treatment strategies for GI cancers
Build Machine Learning based models for cancer diagnosis and prognosis
Gut Microbiota and tumor Microenvirment in Cancer Immunotherapy
The story regarding single-cell based dynamic microenvironment of EBV positive gastric cancer before and after anti-PD1 treatment is published in Signal Transduction and Targeted Therapylink6. June. 2023
Genomic based cancer evolution analysis of Gastric mixed adenoneuroendocrine carcinoma (MANEC) is finally published in Cell Report link22. May. 2023
Our group performed a comprehensive analysis between mutational signatures and tumor microenvironment in pan cancers. The result is published on line at Front. Immunol link1. March . 2023
VSOLassoBag have been published as a cover story in Journal of Genetics and genomics. link24. May . 2022
MPTevol published online in Briefings in bioinformatics! A practical computational framework for comprehensively exploring the Multiple primary tumor(MPT) from multiregion sequencing (MRS) experiments. link29. April . 2022
Our team lead by Prof Xu reported main result of Chankang project: Genomic analysis of 1015 Chinese ColorectalCancer patients reveals a subgroup defined by mitochondrial genomic alterations link