A multidisciplinary bioinformatics team at Sun Yat-sen University Cancer Center, advancing gastrointestinal cancer research through computational biology, machine learning, and multi-omics analysis.
🎉 Latest Highlight: Our gastric cancer immunochemotherapy resistance study is featured as the cover article in Cancer Cell (2026), unveiling five tumor microenvironment ecotypes and a novel multi-omics stratification system for precision treatment.
Our research spans several interconnected areas:
Mining multi-omics data to spot biomarkers that flag immunotherapy responders, then packaging those signals into clinical assays for patient selection and combo dosing.
Shipping open-source algorithms, containerized workflows and curated databases that let the community reproduce and extend large-scale cancer genomics studies.
Scanning exome, transcriptome and drug-screen datasets to surface druggable lesions in GI tumors, mapping trials to the right inhibitors and tracing resistance with real-time liquid biopsies.
Training lightweight models on pathology images, radiology scans and routine labs to flag early-stage tumors, forecast survival and explain calls in clinician-friendly heat-maps.
Tracking gut-bug shifts during ICI treatment, testing causality in germ-free models and crafting next-gen probiotics that sharpen anti-tumor immunity.

We are thrilled to announce that our latest research on gastric cancer has been published as a cover article in Cancer Cell! This groundbreaking study dissects the mechanisms underlying resistance to neoadjuvant immunochemotherapy in gastric cancer and proposes a novel multi-omics stratification system.
Based on the NEOSUMMIT-01 clinical trial with 110 gastric cancer patients, we identified five distinct tumor microenvironment ecotypes (EC1-5) that predict therapeutic response. Our findings reveal that EC5 resistance is mediated by interactions between APOA1+ tumor cells and TREM2+ macrophages, opening new avenues for overcoming treatment resistance.
Congratulations to the entire team for this remarkable achievement!

Our new ecDNA allocation algorithm GCAP is now live! linc. Congratulations to Shixiang Wang! GCAP enables determination of ecDNA status from whole-exome sequencing (WES) datasets. Using GCAP, we further reveal that ecDNA may serve as a promising biomarker for ICI treatment in gastrointestinal (GI) cancers.

“We developed a bioinformatics tool repository for indexing and commenting thousands of tools, which was recently highlighted as a cover story in Science China Life Sciences.” linc

“Our study on the single-cell dynamic microenvironment of EBV-positive gastric cancer before and after anti-PD1 treatment” is now published in Signal Transduction and Targeted Therapy. link