Our Gastric Cancer Study Featured as Cancer Cell Cover Article

We are thrilled to announce that our latest research on gastric cancer has been published as a cover article in Cancer Cell! This groundbreaking study dissects the mechanisms underlying resistance to neoadjuvant immunochemotherapy in gastric cancer and proposes a novel multi-omics stratification system.

Based on the NEOSUMMIT-01 clinical trial with 110 gastric cancer patients, we identified five distinct tumor microenvironment ecotypes (EC1-5) that predict therapeutic response. Our findings reveal that EC5 resistance is mediated by interactions between APOA1+ tumor cells and TREM2+ macrophages, opening new avenues for overcoming treatment resistance.

Congratulations to the entire team for this remarkable achievement!

Read the full article